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Additionally, discontinuation of the concomitantly used cytochrome P450 3A4 inducer may possibly result in an increase in fentanyl plasma concentration. Watch patients acquiring DURAGESIC and any CYP3A4 inhibitor or inducer.

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The concomitant utilization of DURAGESIC with all cytochrome P450 3A4 inhibitors may well bring about a rise in fentanyl plasma concentrations, which could improve or prolong adverse drug results and could induce perhaps deadly respiratory despair.

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